Genetics of Type 1A Diabetes

In 1976, the noted human geneticist James Neel titled a book chapter "Diabetes Mellitus: A Geneticist's Nightmare."1 Over the past 30 years, however, the phenotypic and genetic heterogeneity of diabetes has been painstakingly teased apart to reveal a family of disorders that are all characterized by the disruption of glucose homeostasis but that have fundamentally different causes. Recently, the availability of detailed information on the structure and variation of the human genome and of new high-throughput techniques for exploiting these data has geneticists dreaming of unraveling the genetic complexity that underlies these disorders. This review focuses on type 1 diabetes . . .

Source Information

From the Center for Public Health Genomics (P.C., S.S.R.) and the Departments of Biochemistry and Molecular Genetics (P.C.) and Public Health Sciences (S.S.R.), University of Virginia, Charlottesville; and the Diabetes Research Program, Benaroya Research Institute, Seattle (G.T.N.).

Address reprint requests to Dr. Concannon at the Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, or at patcon@virginia.edu.
open with PDF